Lane 1: Human colon
Lane 2: SH-SY-5Y
Lane 3: SiHa
Lane 4: K562
Recombinant Rabbit monoclonal primary
Recombinant DDX6 Monoclonal Antibody (ET7107-06)
Rat brain tissue, human tonsil tissue, human kidney tissue, mouse small intestine tissue, human colon tissue, SH-SY-5Y, K562, SiHa.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Probable ATP-dependent RNA helicase DDX6
DDX6, HLR2, RCK
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
Abundantly expressed in most tissues.
Cytoplasm, P-body. Cytoplasm. Nucleus. Note=Upon cellular stress, relocalizes to stress granules.
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.