Recombinant Rabbit monoclonal primary
Recombinant Dcp1a Monoclonal Antibody (ET7107-26)
Recombinant protein within c terminal human dcp1a.
LOVO, SH-SY-5Y, SiHa, human liver tissue, human placenta tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
63 kDa(Predicted band size)
mRNA-decapping enzyme 1A
Belongs to the DCP1 family.
Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
Cytoplasm, P-body. Nucleus. Note=Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4.
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.