Recombinant Rabbit monoclonal primary
Recombinant DARPP32 Monoclonal Antibody (ET1608-23)
SH-SY-5Y, MCF-7, mouse brain tissue, rat brain tissue, human gastric carcinoma tissue, human breast carcinoma tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
DARPP 32 antibody; DARPP-32 antibody; Dopamine and cAMP regulated neuronal phosphoprotein 32 antibody; Dopamine and cAMP regulated neuronal phosphoprotein antibody; Dopamine and cAMP regulated phosphoprotein antibody; Dopamine and cAMP regulated phosphoprotein DARPP 32 antibody; Dopamine and cAMP regulated phosphoprotein DARPP32 antibody; Dopamine- and cAMP-regulated neuronal phosphoprotein antibody; FLJ20940 antibody; IPPD antibody; Neuronal phosphoprotein DARPP 32 antibody; PPP1R1B antibody; PPR1B_HUMAN antibody; Protein phosphatase 1 regulatory (inhibitor) subunit 1B antibody; Protein phosphatase 1 regulatory inhibitor subunit 1B antibody; Protein phosphatase 1 regulatory subunit 1B antibody
Belongs to the protein phosphatase inhibitor 1 family.
Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.; Phosphorylation of Thr-34 is required for activity.
Dopaminergic signaling pathways, which are essential for multiple brain functions, are abnormal in several neurological disorders, such as schizophrenia, Parkinson's disease and drug abuse. DARPP-32 (for dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein) is abundant in neurons that receive dopaminergic input. Activation of PKA and the consequent phosphorylation of DARPP-32 on threonine occurs in response to dopamine acting upon D1-like receptors. Dopamine interaction with D2-like receptors results in the inhibition of PKA activation, the activation of protein phosphatase 2B and the consequent dephosphorylation of DARPP-32. Neurotransmitters other than dopamine may also be able to stimulate the phosphorylation or dephosphorylation of DARPP-32. Phosphorylated DARPP-32 is a potent inhibitor of PP-1.