UNIPROT #

Q9UD71

PROTEIN NAME

DARPP32

SYNONYMS

DARPP 32 antibody; DARPP-32 antibody; Dopamine and cAMP regulated neuronal phosphoprotein 32 antibody; Dopamine and cAMP regulated neuronal phosphoprotein antibody; Dopamine and cAMP regulated phosphoprotein antibody; Dopamine and cAMP regulated phosphoprotein DARPP 32 antibody; Dopamine and cAMP regulated phosphoprotein DARPP32 antibody; Dopamine- and cAMP-regulated neuronal phosphoprotein antibody; FLJ20940 antibody; IPPD antibody; Neuronal phosphoprotein DARPP 32 antibody; PPP1R1B antibody; PPR1B_HUMAN antibody; Protein phosphatase 1 regulatory (inhibitor) subunit 1B antibody; Protein phosphatase 1 regulatory inhibitor subunit 1B antibody; Protein phosphatase 1 regulatory subunit 1B antibody

SEQUENCE SIMILARITIES

Belongs to the protein phosphatase inhibitor 1 family.

POST-TRANSLATIONAL MODIFICATION

Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.; Phosphorylation of Thr-34 is required for activity.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Dopaminergic signaling pathways, which are essential for multiple brain functions, are abnormal in several neurological disorders, such as schizophrenia, Parkinson's disease and drug abuse. DARPP-32 (for dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein) is abundant in neurons that receive dopaminergic input. Activation of PKA and the consequent phosphorylation of DARPP-32 on threonine occurs in response to dopamine acting upon D1-like receptors. Dopamine interaction with D2-like receptors results in the inhibition of PKA activation, the activation of protein phosphatase 2B and the consequent dephosphorylation of DARPP-32. Neurotransmitters other than dopamine may also be able to stimulate the phosphorylation or dephosphorylation of DARPP-32. Phosphorylated DARPP-32 is a potent inhibitor of PP-1.