Recombinant Rabbit monoclonal primary
Recombinant Cytochrome P450 2D6 Monoclonal Antibody (ET1705-28)
HepG2, SW480, human liver tissue, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Cytochrome P450 2D6
CPD6 antibody; CYP2D antibody; CYP2D6 antibody; CYP2D7AP antibody; CYP2D7BP antibody; CYP2D7P2 antibody; CYP2D8P2 antibody; CYP2DL1 antibody; CYPIID6 antibody; Cytochrome P450 DB1 antibody; Cytochrome P450 family 2 subfamily D member 6 antibody; Cytochrome P450 family 2 subfamily D polypeptide 6 antibody; Debrisoquine 4 hydroxylase antibody; Flavoprotein linked monooxygenase antibody; Microsomal monooxygenase antibody; P450 DB1 antibody; P450C2D antibody; P450DB1 antibody; Xenobiotic monooxygenase antibody
Belongs to the cytochrome P450 family.
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
The P450II family comprises at least five subfamilies, designated A through E by the system of nomenclature recommended by an international committee. The P450IID subfamily comprises at least two genes in the rat, one of which is highly specific for debrisoquine 4-hydroxylase activity. An association of this gene with lung cancer has been found. Enhanced CYP2D6 activity has been related to malignancies of the bladder, liver, pharynx and stomach, and especially to cigarette-smoking-induced lung cancer. The data suggests that enhanced CYP2D6-mediated metabolism of one or more dietary and other environmental agents, to form a reactive intermediate, plays a role in cancer initiation and/or promotion in various tissues. CYP2D6 polymorphism, which is responsible for the variation in metabolism of debrisoquine 4-hydroxylase, is important in the metabolism of more than 30 drugs and environmental chemicals, including as much as 20% of all commonly prescribed drugs. The gene which encodes CYP2D6 maps to human chromosome 22q13.1.