Lane 1: Hela cell lysate
Lane 2: 293 cell lysate
Lane 3: HepG2 cell lysate
Lane 4: NIH/3T3 cell lysate
Recombinant Rabbit monoclonal primary
Recombinant CPT2 Monoclonal Antibody (ET1611-64)
Hela cell lysate, 293 cell lysate, HepG2 cell lysate, NIH/3T3 cell lysate, HepG2, SW480, human liver carcinoma tissue, human kidney tissue, mouse kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Carnitine O palmitoyltransferase 2 antibody; Carnitine O palmitoyltransferase 2 mitochondrial antibody; Carnitine O-palmitoyltransferase 2 antibody; Carnitine palmitoyltransferase 2 antibody; Carnitine palmitoyltransferase II antibody; CPT 1 antibody; CPT 2 antibody; CPT II antibody; CPT1 antibody; CPT2 antibody; CPT2_HUMAN antibody; CPTASE antibody; CPTII antibody; IIAE4 antibody; mitochondrial antibody
Belongs to the carnitine/choline acetyltransferase family.
Mitochondrion inner membrane.
The mitochondrial β-oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase (CPT) I (outer membrane and detergent labile) and II (inner membrane and detergent stable), together with carnitine carrier. CPTI catalyzes the first reaction in the transport of long-chain fatty acids from the cytoplasm to the mitochondrion, a rate-limiting step in beta-oxidation. Two types of CPTI are known, the liver (CPTIA) and muscle (CPTIB) isoforms. The muscle type protein is specially expressed in heart and skeletal muscle. Membrane-bound CPTI, but not CPTII, is inhibited reversibly by malonyl-coenzyme A (CoA). Unlike CPTII, CPTI requires membrane integrity for catalytic function. In addition, glutamic acid 3 and histidine 5 are necessary for malonyl CoA inhibition and binding to liver CPTI, but not for catalytic activity.