Lane 1: C2C12 cell lysate
Lane 2: A431 cell lysate
Recombinant Rabbit monoclonal primary
Recombinant COX1/Cyclooxygenase 1 Monoclonal Antibody (ET1610-98)
C2C12, A431, Hela, N2A, L6, mouse skin tissue, mouse brain tissue, human breast cancer tissue, mouse stomach tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Prostaglandin G/H synthase 1
COX-1, PGH synthase 1, PGHS-1, PHS 1, PTGS1
Belongs to the prostaglandin G/H synthase family.
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.