Lane 1: mouse heart tissue lysate
Lane 2: rat heart tissue lysate
Lane 3: MCF-7 cell lysate
Recombinant Rabbit monoclonal primary
Recombinant COX IV Monoclonal Antibody (ET1701-63)
NIH/3T3, HepG2, human liver tissue, mouse heart tissue, rat heart tissue, mouse colon tissue, human liver cancer tissue, human colon cancer tissue, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
COX IV-1, COX4I1
Belongs to the cytochrome c oxidase IV family.
Mitochondrion inner membrane; Single-pass membrane protein.
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.