Lane 1: Hela
Lane 2: Jurkat
Recombinant Rabbit monoclonal primary
Recombinant CDC5L Monoclonal Antibody (ET1701-75)
Jurkat, MCF-7, Hela, HepG2, NIH/3T3, 293T, SH-SY-5Y, human kidney tissue, mouse lung tissue, mouse kidney tissue, mouse stomach tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Cell division cycle 5-like protein
Cdc5-like protein, CDC5L
Belongs to the CEF1 family.
Ubiquitously expressed in both fetal and adult tissues.
Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8.
Nucleus. Nucleus speckle. Cytoplasm. Note=May shuttle between cytoplasm and nucleus.
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).