Recombinant CDC42EP1 Monoclonal Antibody (ET1612-95)

Western blot analysis of CDC42EP1 on different lysates using anti-CDC42EP1 antibody at 1/1,000 dilution.<br />
Positive control: <br />
Lane 1: HUVEC <br />
Lane 2: Hela

Western blot analysis of CDC42EP1 on different lysates using anti-CDC42EP1 antibody at 1/1,000 dilution.
Positive control:
Lane 1: HUVEC
Lane 2: Hela

Applications

REACTIVITY

Human

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant CDC42EP1 Monoclonal Antibody (ET1612-95)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

HUVEC, Hela.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SD08-54

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

60 kDa

Isotype

IgG

APPLICATION DILUTION

WB
1:1,000-1:2,000

TARGET

UNIPROT #

Q00587

PROTEIN NAME

CDC42EP1

SYNONYMS

55 kDa bone marrow stromal/endothelial cell protein antibody; Binder of Rho GTPases 5 antibody; Bone marrow stromal/endothelial cell protein, 55-KD antibody; BORG 5 antibody; BORG5 antibody; BORG5_HUMAN antibody; CDC42 effector protein (Rho GTPase binding) 1 antibody; Cdc42 effector protein 1 antibody; Cdc42ep1 antibody; CEP 1 antibody; CEP1 antibody; MGC15316 antibody; MSE 55 antibody; MSE55 antibody; OTTHUMP00000028709 antibody; Serum constituent protein antibody; Serum protein MSE55 antibody

SEQUENCE SIMILARITIES

Belongs to the BORG/CEP family.

TISSUE SPECIFICITY

Endothelial and bone marrow stromal cells.

SUBCELLULAR LOCATION

Endomembrane system, Cytoplasm.

FUNCTION

MSE55 also known as Borg5 or binder of Rho GTPases 5 is a Cdc42 effector protein that induces long cellular extensions in fibroblasts. MSE55 also increases and mediates actin cytoskeleton reorganization at the plasma membrane. MSE55 is a nonkinase CRIB (Cdc42/Rac interactive-binding) domain-containing molecule. An intact CRIB domain is required for the GTP-dependent binding of MSE55 to Cdc42. MSE55 is expressed in a tissue-specific manner in endothelial and bone marrow stromal cells. MSE55 may have a functional role in hematopoiesis or as a negative regulator of Rho GTPase signaling.