PRODUCT CODE: ET1702-95

Recombinant CD80 Monoclonal Antibody (ET1702-95)

  • Recombinant

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant CD80 Monoclonal Antibody (ET1702-95)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Human tonsil tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JF100-4

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

60 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IHC-P

  • 1:50-1:100

TARGET

UNIPROT #

PROTEIN NAME

CD80

SYNONYMS

Activation B7-1 antigen antibody; B lymphocyte activation antigen B7 antibody; B7 antibody; B7-1 antibody; B7-1 antigen antibody; B7.1 antibody; BB1 antibody; CD28 antigen ligand 1 antibody; CD28LG antibody; CD28LG1 antibody; CD80 antibody; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) antibody; CD80 antigen antibody; CD80 molecule antibody; CD80_HUMAN antibody; Costimulatory factor CD80 antibody; costimulatory molecule variant IgV-CD80 antibody; CTLA-4 counter-receptor B7.1 antibody; LAB7 antibody; T-lymphocyte activation antigen CD80 antibody

TISSUE SPECIFICITY

Expressed on activated B-cells, macrophages and dendritic cells.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells, bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counterreceptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.