Lane 1: THP-1 cell lysate
Lane 2: Raji cell lysate
Recombinant Rabbit monoclonal primary
Recombinant CD38 Monoclonal Antibody (ET1611-66)
THP-1 cell lysate, Raji cell lysate, human tonsil tissue, human spleen tissue, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Acute lymphoblastic leukemia cells antigen CD38 antibody; ADP ribosyl cyclase 1 antibody; ADP ribosyl cyclase antibody; ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody; ADP-ribosyl cyclase 1 antibody; ADPRC 1 antibody; ADPRC1 antibody; cADPr hydrolase 1 antibody; CD 38 antibody; CD38 antibody; CD38 antigen (p45) antibody; CD38 antigen antibody; CD38 molecule antibody; Cd38-rs1 antibody; CD38_HUMAN antibody; CD38H antibody; Cyclic ADP ribose hydrolase antibody; Cyclic ADP ribose hydrolase 1 antibody; Cyclic ADP-ribose hydrolase 1 antibody; EC 188.8.131.52 antibody; Ecto nicotinamide adenine dinucleotide glycohydrolase antibody; I-19 antibody; I19 (mouse) antibody; Lymphocyte differentiation antigen CD38 antibody; NAD(+) nucleosidase antibody; NIM-R5 antigen antibody; NIMR5 antigen (mouse) antibody; OTTHUMP00000158633 antibody; OTTHUMP00000217743 antibody; p45 antibody; T10 antibody
Belongs to the ADP-ribosyl cyclase family.
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lymphocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabolites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.