Lane 2: 293 cell lysate
Lane 2: Jurkat cell lysate
Lane 2: HUVEC cell lysate
Lane 1: human lung carcinoma tissue lysate
Recombinant Rabbit monoclonal primary
Recombinant Caspase-2 Monoclonal Antibody (ET1602-30)
Recombinant protein within human caspase-2 aa 326-452.
293 cell lysate, Jurkat cell lysate, HUVEC cell lysate, human lung carcinoma tissue lysate, Hela, A549, human lung carcinoma tissue, human kidney tissue, mouse kidney tissue, Jurkat.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Belongs to the peptidase C14A family.
Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
The mature protease can process its own propeptide, but not that of other caspases.
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress.