Lane 1: THP-1 cell lysate
Lane 2: Jurkat cell lysate
Recombinant Rabbit monoclonal primary
Recombinant Caspase-1 Monoclonal Antibody (ET1608-69)
THP-1, Jurkat, human lung cancer tissue, mouse liver tissue, human lung tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
CASP-1, IL-1BC, ICE, IL-1 beta-converting enzyme, CASP1
Belongs to the peptidase C14A family.
Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Cytoplasm. Cell membrane.
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly.
Zhang, Peng et al.
Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation. | The Journal of Biological Chemistry