Recombinant Rabbit monoclonal primary
Recombinant CaMKII alpha Monoclonal Antibody (ET1703-54)
SH-SY5Y, rat brain cells.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Alpha CaMKII antibody; Calcium calmodulin dependent protein kinase II antibody; Calcium/calmodulin dependent protein kinase II alpha B subunit antibody; Calcium/calmodulin dependent protein kinase type II alpha chain antibody; Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha antibody; Calcium/calmodulin-dependent protein kinase II alpha antibody; Calcium/calmodulin-dependent protein kinase II-alpha antibody; Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody; Calcium/calmodulin-dependent protein kinase type IIA antibody; CaM kinase II alpha chain antibody; CaM kinase II alpha subunit antibody; CaM kinase II subunit alpha antibody; CaMK II alpha subunit antibody; CaMK-II subunit alpha antibody; Camk2a antibody; CAMKA antibody; CaMKII antibody; CaMKIINalpha antibody; EC 22.214.171.124 antibody; KCC2A_HUMAN antibody; KIAA0968 antibody; MGC123320 antibody; MGC139375 antibody; MGC155201 antibody; mKIAA0968 antibody; PK2CDD antibody; PKCCD antibody; R74975 antibody; zgc:112538 antibody; zgc:123320 antibody
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state.; Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7.
Cell junction, synapse, presynaptic cell membrane.
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory Threonine residue at position 177.