Applications
-
WB
-
FC
REACTIVITY
-
Human
-
Zebrafish
SPECIFICATIONS
Product Type
Recombinant Rabbit monoclonal primary
Product Name
Recombinant BPI Monoclonal Antibody (ET1611-6)
Immunogen
Recombinant protein
Host
Rabbit
Positive Control
THP-1.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
SN06-63
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein A purified.
MOLECULAR WEIGHT
57 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:1,000-1:2,000
-
FC
-
1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
BPI
SYNONYMS
Bactericidal permeability-increasing protein antibody; bactericidal/permeability-increasing protein antibody; BPI antibody; BPI fold containing family D, member 1 antibody; BPIFD1 antibody; CAP 57 antibody; rBPI antibody; recombinant BPI holoprotein, rBPI antibody
SEQUENCE SIMILARITIES
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
TISSUE SPECIFICITY
Restricted to cells of the myeloid series.
SUBCELLULAR LOCATION
Secreted, Cytoplasmic granule membrane.
FUNCTION
The bactericidal permeability increasing protein (BPI) is an antibacterial and endotoxin-neutralizing molecule that is abundant in the granules of polymorphonuclear leukocytes (neutrophil granules). The 31.5-kb-long human BPI gene maps to chromosome 20q11.23-q12, contains 15 exons, and encodes a 456 amino acid protein. Epithelial cells which line mucosal surfaces are the first line of defense against bacterial invasion and infection. BPI localizes to the cell surface of epithelial cells and blocks endotoxin-mediated signaling, thereby protecting mucosal surfaces against gram-negative bacteria and their endotoxin. BPI, lipopolysaccharide binding protein (LBP), phospholipid transfer protein (PLTP), and cholesteryl ester transfer protein (CETP) constitutes a family of functionally related proteins.