UNIPROT #

P07550

PROTEIN NAME

beta 2 Adrenergic Receptor

SYNONYMS

ADRB2 antibody; ADRB2_HUMAN antibody; ADRB2R antibody; ADRBR antibody; Adrenergic beta 2 receptor surface antibody; Adrenoceptor beta 2 surface antibody; B2AR antibody; BAR antibody; beta 2 adrenoceptor antibody; Beta 2 adrenoreceptor antibody; Beta-2 adrenergic receptor antibody; Beta-2 adrenoceptor antibody; Beta-2 adrenoreceptor antibody; BETA2AR antibody; Catecholamine receptor antibody; OTTHUMP00000160386 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.

POST-TRANSLATIONAL MODIFICATION

Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.; Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.; Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.; Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent.; Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.

SUBCELLULAR LOCATION

Cell membrane, Early endosome.

FUNCTION

Adrenergic receptors (ARs) (the term "adrenergic" reflects the alternative name for epinephrine, adrenaline) include four general types (a1, a2, b1 and b2) which are found in different target tissues and differ in their affinities and responses to various agonists and antagonists. cDNA clones have been isolated for all of the major AR subtypes and a number of closely related receptors have been identified by this approach. Each of the receptors have been shown to consist of single polypeptide chains which transverse the plasma membrane seven times, presumably forming a bundle of helices within the membrane. These transmembrane regions are hydrophobic and are interconnected by extracellular and intracellular hydrophilic loops. The coupling of ARs to specific intracellular effectors is mediated through diverse heterotrimeric G proteins and is regulated by G protein-coupled receptor kinases (GRKs), cAMP-dependent protein kinase A and protein kinase C directed phosphorylation. b2-adrenergic receptors bind cathecholamines (epinephrine, norepinephrine) and influence development, behavior, cardiac function, smooth muscle tone, and metabolism. b2-AR signaling complexes can contain C L-type calcium channel Ca(V)1.2, G protein, adenylyl cyclase, cAMP-dependent kinase, and PP2A phosphatase.