Recombinant Rabbit monoclonal primary
Recombinant Bag3 Monoclonal Antibody (ET1704-73)
Hela, MCF-7, human fetal skeletal muscle tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
BAG 3 antibody; BAG family molecular chaperone regulator 3 antibody; BAG-3 antibody; Bag3 antibody; BAG3_HUMAN antibody; Bcl 2 binding protein antibody; Bcl-2-associated athanogene 3 antibody; Bcl-2-binding protein Bis antibody; BCL2 associated athanogene 3 antibody; BCL2 binding athanogene 3 antibody; BIS antibody; CAIR 1 antibody; Docking protein CAIR 1 antibody; Docking protein CAIR-1 antibody; MFM6 antibody
The Bag family of proteins are characterized by the presence of a 45 amino acid Bag domain through which they bind with high affinity to the ATPase domain of HSP 70, thereby negatively regulating HSP 70 chaperone activity. Bag-3 (Bcl-2-associated athanogene 3), also known as BIS or CAIR-1, is a 575 amino acid protein that contains one C-terminal Bag domain and two N-terminal WW domains. Like other members of the Bag family, Bag-3 functions to inhibit the chaperone activity of HSP 70, specifically by promoting the release of HSP 70-bound substrates. Additionally, Bag-3 exhibits anti-apoptotic activity via cell cycle control, suggesting a possible role for Bag-3 in tumor progression. The gene encoding Bag-3 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.