Recombinant Rabbit monoclonal primary
Recombinant ARF6 Monoclonal Antibody (ET1702-91)
MCF-7, Hela, HepG2, human liver tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
ADP ribosylation factor 6 antibody; ADP ribosylation factor protein 6 antibody; ADP-ribosylation factor 6 antibody; ARF6 antibody; ARF6_HUMAN antibody; DKFZp564M0264 antibody; Small GTP binding protein antibody; Small GTPase antibody
Belongs to the small GTPase superfamily. Arf family.
Ubiquitous, with higher levels in heart, substantia nigra, and kidney.
Golgi apparatus, Cell membrane, Endosome membrane, Cell projection, Midbody, Cytoplasm, Cleavage furrow.
The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF-dependent regulatory mechanisms include the coordination of spectrin interactions with golgi membranes and the association of Actin to the Golgi via rho family-dependent G-protein localization (Rac, CDC42) and WASP/Arp2/3 complexes. Additionally, ARFs play a central role in maintenance of organelle integrity, assembly of coat proteins and activation of phospholipase D. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6); members of each class share a common gene organization. The human ARF6 gene contains five exons and four introns, and encodes a 175 amino acid protein.