Recombinant Rabbit monoclonal primary
Recombinant Angiopoietin 1 Monoclonal Antibody (ET1611-28)
K562 cell lysates.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
AGP 1 antibody; AGP1 antibody; AGPT antibody; ANG 1 antibody; ANG antibody; ANG-1 antibody; ANG1 antibody; Angiopoietin-1 antibody; Angiopoietin1 antibody; ANGP1_HUMAN antibody; ANGPT 1 antibody; Angpt1 antibody; KIAA0003 antibody; OTTHUMP00000227592 antibody; OTTHUMP00000227599 antibody; OTTHUMP00000227600 antibody
Tie-1 and Tie-2 (also designated Tek) are novel cell surface receptor tyrosine kinases. The extracellular domain of Tie-1 has an unusual multidomain structure consisting of a cluster of three epidermal growth factor homology motifs localized between two immunoglobulin-like loops, which are followed by three fibronectin type III repeats next to the transmembrane region. Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2. Preliminary biochemical analyses of Ang-1 reveal a potential fibrinogen-like domain at the carboxy terminus and coiled-coil regions in the amino terminus. Ang-1 is an angiogenic factor that is thought to be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), has been identified as a naturally occurring antagonist of Ang-1 activation of Tie-2. In adult tissue, Ang-2 expression seems to be restricted to sites of vascular remodeling.