Recombinant Rabbit monoclonal primary
Recombinant Adiponectin receptor protein 1 Monoclonal Antibody (ET1610-86)
Hela, HepG2, LO2, human kidney tissue, mouse liver tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Adiponectin receptor protein 1
ACDCR1 antibody; ADIPO R1 antibody; Adiponectin receptor protein 1 antibody; ADIPOR 1 antibody; Adipor1 antibody; ADR1_HUMAN antibody; CGI 45 antibody; CGI 45 protein antibody; CGI-45 antibody; CGI45 antibody; CGI45 protein antibody; FLJ25385 antibody; FLJ42464 antibody; PAQR1 antibody; Progestin and adipoQ receptor family member I antibody; TESBP1A antibody
Belongs to the ADIPOR family.
Widely expressed. Highly expressed in heart and skeletal muscle. Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.
Adiponectin is a circulating hormone secreted by adipocytes that improves the metabolism of glucose and lipids, and is expressed at low levels in those with obesity and diabetes. Adiponectin receptors AdipoR1 and AdipoR2, also designated progestin and adipoQ receptor family members I and II, respectively, regulate fatty acid oxidation and the uptake of glucose by adiponectin. Each receptor activates a unique set of signaling molecules including AMPK, p38 MAPK and PPARα. AdipoR1 has a high-affinity for globular adiponectin and low-affinity for full-length adiponectin, while AdipoR2 has an intermediate affinity for both forms. AdipoR1 and AdipoR2 are mainly expressed in liver and muscle. Adiponectin, AdipoR1 and AdipoR2 are all associated with body composition, Insulin sensitivity, and metabolic parameters. Physical training increases circulating adiponectin and mRNA expression of AdipoR1 and AdipoR2 in muscle, which may mediate the improvement of Insulin resistance and the metabolic syndrome in response to exercise.