Recombinant Rabbit monoclonal primary
Recombinant ADAM17 Monoclonal Antibody (ET1703-06)
SW480 cell lysates, HepG2, SKOV-3, SW480, Hela.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) antibody; A disintegrin and metalloproteinase domain 17 antibody; ADA17_HUMAN antibody; ADAM 17 antibody; ADAM metallopeptidase domain 17 antibody; ADAM17 antibody; ADAM17 protein antibody; CD 156b antibody; CD156b antibody; CD156b antigen antibody; CSVP antibody; Disintegrin and metalloproteinase domain-containing protein 17 antibody; MGC71942 antibody; NISBD antibody; NISBD1 antibody; Snake venom like protease antibody; Snake venom-like protease antibody; TACE antibody; TNF alpha convertase antibody; TNF alpha converting enzyme antibody; TNF-alpha convertase antibody; TNF-alpha-converting enzyme antibody; Tumor Necrosis Factor Alpha Converting Enzyme antibody
Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
The precursor is cleaved by a furin endopeptidase.; Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791. Phosphorylation at THR-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding.
Tumor necrosis factor β (TNFβ), also known as lymphotoxin, is a pleiotropic cytokine. TNFα, also known as cachetin, is a cytokine that binds to the same receptors, producing an array of effects similar to those of TNFβ. TNFβ and TNFα share 30% amino acid homology and have similar biological activities. TNFβ is produced by activated lymphocytes, including CD4+ T helper cell type 1 lymphocytes, CD8+ lymphocytes and certain B lymphoblastoid cell lines. TNFα is produced by several different cell types, including lymphocytes, neutrophils and macrophages. TNFβ and TNFα can modulate many immune and inflammatory functions while having the ability to inhibit tumor growth. TACE (for TNFα converting enzyme) is a metalloproteinase that cleaves the membrane-bound TNFα precursor to release soluble TNFα.