UNIPROT #

Q9C0K0

PROTEIN NAME

Ctip2

SYNONYMS

ATL1 alpha antibody; ATL1 antibody; ATL1 beta antibody; ATL1 gamma antibody; ATL1-delta antibody; B cell CLL/lymphoma 11B/T cell receptor delta constant region fusion protein antibody; B cell lymphoma/leukemia 11B antibody; B-cell CLL/lymphoma 11B (zinc finger protein) antibody; B-cell CLL/lymphoma 11B antibody; B-cell lymphoma/leukemia 11B antibody; BC11B_HUMAN antibody; BCL-11B antibody; Bcl11b antibody; BCL11B/TRDC fusion antibody; COUP TF interacting protein 2 antibody; COUP-TF interacting protein 2 antibody; COUP-TF-interacting protein 2 antibody; Ctip 2 antibody; CTIP-2 antibody; CTIP2 antibody; hRIT1 alpha antibody; hRit1 antibody; Radiation induced tumor suppressor gene 1 antibody; Radiation induced tumor suppressor gene 1 protein antibody; Radiation-induced tumor suppressor gene 1 protein antibody; Rit 1 antibody; Rit1 antibody; zinc finger protein hRit1 alpha antibody; ZNF856B antibody

TISSUE SPECIFICITY

Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.

POST-TRANSLATIONAL MODIFICATION

Sumoylated with SUMO1.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.