Recombinant Rabbit monoclonal primary
Recombinant 5T4 Monoclonal Antibody (ET1608-37)
MCF-7 cell lysates.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
5T4 antibody; 5T4 oncofetal antigen antibody; 5T4 oncofetal trophoblast glycoprotein antibody; 5T4 oncotrophoblast glycoprotein antibody; 5T4AG antibody; AW495680 antibody; M6P1 antibody; TPBG antibody; TPBG_HUMAN antibody; Trophoblast glycoprotein antibody
Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
TPBG (trophoblast glycoprotein), also known as 5T4, M6P1 or 5T4AG, is a 420 amino acid single-pass type I membrane protein expressed by all types of trophoblasts as early as 9 weeks of development. TPBG contains an N-terminal putative signal sequence, a 310-residue extracellular region, a membrane anchorage domain and a 44-amino acid cytoplasmic tail with a potential phosphorylation site. The extracellular region has seven potential N-glycosylation sites and seven leucine-rich repeats, which are located in two regions separated by a hydrophilic stretch. Suggested to be involved in cell adhesion, TPBG may also be associated with tumor growth and progression.