Lane 1: MCF-7 cell lysate
Lane 2: Hela cell lysate
Recombinant Rabbit monoclonal primary
Recombinant 14-3-3 Theta Monoclonal Antibody (ET1612-97)
A431, MCF-7, Hela, A549.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
14-3-3 protein theta
Belongs to the 14-3-3 family.
Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
Ser-232 is probably phosphorylated by CK1.
Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.