Positive control:
Lane 1: Jurkat
Lane 2: A431
Lane 3: K562
Applications
-
WB
-
IHC-P
-
ICC
-
FC
REACTIVITY
-
Human
-
Rat
SPECIFICATIONS
Product Type
Mouse monoclonal primary
Product Name
PTBP1 Monoclonal Antibody (EM1701-63)
Immunogen
Recombinant protein within human ptbp1 aa 320-550.
Host
Mouse
Positive Control
Jurkat, A431, K562, rat testis tissue, human tonsil tissue, human colon cancer tissue, human kidney tissue, 293T, A549, SW480, K562.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
9A1
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2 ug/ul
PURIFICATION
Protein G purified.
MOLECULAR WEIGHT
57 kDa
Isotype
IgG2a
APPLICATION DILUTION
-
WB
-
1:5,000-1:10,000
-
IHC-P
-
1:50-1:100
-
ICC
-
1:50-1:100
-
FC
-
1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
PTBP1
SYNONYMS
57 kDa RNA binding protein PPTB 1 antibody; 57 kDa RNA-binding protein PPTB-1 antibody; Heterogeneous nuclear ribonucleoprotein I antibody; Heterogeneous Nuclear Ribonucleoprotein Polypeptide I antibody; hnRNP I antibody; HNRNP-I antibody; HNRNPI antibody; HNRPI antibody; MGC10830 antibody; MGC8461 antibody; Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I) antibody; Polypyrimidine Tract Binding Protein 1 antibody; Polypyrimidine tract binding protein antibody; Polypyrimidine tract-binding protein 1 antibody; pPTB antibody; PTB 1 antibody; PTB 2 antibody; PTB 3 antibody; PTB 4 antibody; PTB antibody; PTB T antibody; PTB1 antibody; PTB2 antibody; PTB3 antibody; PTB4 antibody; PTBP 1 antibody; PTBP1 antibody; PTBP1_HUMAN antibody; PTBT antibody; RNA Binding Protein antibody
SUBCELLULAR LOCATION
Nucleus.
FUNCTION
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.