Lane 1: Jurkat
Lane 2: A431
Lane 3: K562
Mouse monoclonal primary
PTBP1 Monoclonal Antibody (EM1701-63)
Recombinant protein within human ptbp1 aa 320-550.
Jurkat, A431, K562, rat testis tissue, human tonsil tissue, human colon cancer tissue, human kidney tissue, 293T, A549, SW480, K562.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein G purified.
Polypyrimidine tract-binding protein 1
PTB, hnRNP I, PTBP1, PTB
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.