Rabbit polyclonal primary
Orai1 Antibody (ER1803-11)
Synthetic peptide within mouse orai1 aa 150-250.
PC-3M, LOVO, MCF-7, human skin tissue, human esophagus tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Calcium release-activated calcium channel protein 1
ORAI1, CRACM1, TMEM142A
Belongs to the Orai family.
Expressed in naive CD4 and CD8 T cells (at protein level). Expressed at similar levels in naive and effector T helper cells.
N-glycosylated. N-glycosylation inhibits channel activity in T cells.; Ubiquitinated.; Cys-195 is oxidated, leading to inactivation of channel activity.
Cell membrane; Multi-pass membrane protein. Note=Isoform beta is more mobile in the plasma membrane. Colocalizes with STIM1 at the cell membrane.
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.