Rabbit polyclonal primary
OOEP Antibody (ER50105)
Mouse ovary tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified
Oocyte-expressed protein homolog
Belongs to the KHDC1 family.
Expressed in ovaries, where it is restricted to growing oocytes, with greatest levels in fully grown oocytes.
Transcripts first detected at 15.5 dpc and peak 1 week after birth. Transcripts accumulate during oogenesis. During meiotic maturation, the vast majority of the transcripts are degraded and virtually none is detected by 2-cell stage embryogenesis. The protein however persists during preimplantation up to the blastocyst stage. At 2-cell stage, excluded from cell-cell contact regions. Continuous exclusion from these regions during preimplantation development leads to the absence of the protein from the inner cells of the morula and the inner cell mass of the blastocyst.
Cytoplasm. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions.
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.