UNIPROT #

Q9CWE6

PROTEIN NAME

OOEP

SYNONYMS

C6orf156 antibody; FLOPED antibody; HOEP19 antibody; KH homology domain-containing protein 2 antibody; KHDC2 antibody; Oocyte expressed protein antibody; Oocyte- and embryo-specific protein 19 antibody; Oocyte-expressed protein homolog antibody; OOEP antibody; OOEP_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the KHDC1 family.

TISSUE SPECIFICITY

Expressed in ovaries, where it is restricted to growing oocytes, with greatest levels in fully grown oocytes.

DEVELOPMENTAL STAGE

Transcripts first detected at 15.5 dpc and peak 1 week after birth. Transcripts accumulate during oogenesis. During meiotic maturation, the vast majority of the transcripts are degraded and virtually none is detected by 2-cell stage embryogenesis. The protein however persists during preimplantation up to the blastocyst stage. At 2-cell stage, excluded from cell-cell contact regions. Continuous exclusion from these regions during preimplantation development leads to the absence of the protein from the inner cells of the morula and the inner cell mass of the blastocyst.

SUBCELLULAR LOCATION

Cytoplasm

FUNCTION

OOEP (oocyte-expressed protein homolog), also known as KHDC2 (KH homology domain-containing protein 2) or OEP19 (oocyte- and embryo-specific protein 19), is a 149 amino acid cytoplasmic protein that belongs to the KHDC1 family and contains one KH domain. As a member of the subcortical maternal complex (SCMC), OOEP is necessary for zygotes to progress beyond the first embryonic cell divisions. In addition to OOEP, the SCMC includes NALP5 and TLE6. The gene that encodes OOEP consists of approximately 26,579 bases and maps to human chromosome 6q13. With 170 million base pairs, chromosome 6 comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.