Lane 1: K562 cell lysate
Lane 2: A431 cell lysate
Rabbit polyclonal primary
Nucleoporin p62 Antibody (ER2001-57)
Synthetic peptide within human nucleoporin p62 aa 470-522.
K562 cell lysate, A431 cell lysate, human breast carcinoma tissue, human rectum tissue.
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Predicted band size: 53 kDa.
Nuclear pore glycoprotein p62 62 kDa nucleoporin Nucleoporin Nup62
Cytoplasm, Cytoskeleton, Nuclear pore complex, Nucleus.
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown.