NMDAR1 Recombinant Rabbit Monoclonal Antibody [JM11-26] (ET1703-75)

UNIPROT #

Q05586

PROTEIN NAME

NMDAR1

SYNONYMS

GluN1 antibody;Glutamate [NMDA] receptor subunit zeta-1 antibody;Glutamate receptor ionotropic N methyl D aspartate 1 antibody;Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1 antibody;glutamate receptor ionotropic, NMDA 1 antibody;Grin1 antibody;MRD8 antibody;N methyl D aspartate receptor antibody;N methyl D aspartate receptor channel subunit zeta 1 antibody;N methyl D aspartate receptor subunit NR1 antibody;N-methyl-D-aspartate receptor subunit NR1 antibody;NMD-R1 antibody;NMDA 1 antibody;NMDA R1 antibody;NMDA receptor 1 antibody;NMDA1 antibody;NMDAR antibody;NMDZ1_HUMAN antibody;NR1 antibody

SEQUENCE SIMILARITIES

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.

POST-TRANSLATIONAL MODIFICATION

NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.

SUBCELLULAR LOCATION

Cell membrane, postsynaptic cell membrane, postsynaptic density.

FUNCTION

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+.Sensitivity to glutamate and channel kinetics depend on the subunit composition.