UNIPROT #

O00712

PROTEIN NAME

NFIB NF1B2

SYNONYMS

CCAAT Box Binding Transcription Factor antibody; CCAAT-box-binding transcription factor antibody; CTF antibody; HMGIC/NFIB antibody; NF-I/B antibody; NF1-B antibody; NF1B antibody; NF1B2 antibody; NFI-B antibody; NFI-RED antibody; Nfib antibody; NFIB_HUMAN antibody; NFIB2 antibody; NFIB3 antibody; Nuclear factor 1 B-type antibody; Nuclear factor 1/B antibody; Nuclear Factor 1B antibody; Nuclear Factor I B antibody; Nuclear factor I/B antibody; TGGCA Binding Protein antibody; TGGCA-binding protein antibody; TRANSCRIPTION FACTOR NFIB antibody

SEQUENCE SIMILARITIES

Belongs to the CTF/NF-I family.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, α-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.