PRODUCT CODE: 0911-5

Netrin receptor DCC Antibody (0911-5)

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Human

  • Mouse

Western blot analysis on Hela using anti- Netrin receptor DCC polyclonal antibody
  • Western blot analysis on Hela using anti- Netrin receptor DCC polyclonal antibody
Western blot analysis on Hela using anti- Netrin receptor DCC polyclonal antibody

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Human

  • Mouse

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

Netrin receptor DCC Antibody (0911-5)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Human brain, mouse brain

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Immunogen affinity purified

MOLECULAR WEIGHT

90 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

TARGET

UNIPROT #

PROTEIN NAME

Netrin receptor DCC

GENE NAME

DCC

SYNONYMS

DCC

SEQUENCE SIMILARITIES

Belongs to the immunoglobulin superfamily. DCC family.

TISSUE SPECIFICITY

Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

SUBCELLULAR LOCATION

Membrane; Single-pass type I membrane protein.

FUNCTION

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.