Applications
-
ICC
-
IHC-P
-
FC
REACTIVITY
-
Human
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
NaV1.7 Antibody (ER1706-44)
Immunogen
Peptide
Host
Rabbit
Positive Control
A549, Hela, SH-SY5Y, human liver cancer tissue, mouse colon tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified.
MOLECULAR WEIGHT
226 kDa
Isotype
IgG
APPLICATION DILUTION
-
ICC
-
1:50-1:200
-
ICC
-
1:50-1:200
-
FC
-
1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
NaV1.7
SYNONYMS
ETHA antibody; GEFSP7 antibody; hNE Na antibody; hNE-Na antibody; hNENa antibody; NE NA antibody; NENA antibody; Neuroendocrine sodium channel antibody; Peripheral sodium channel 1 antibody; PN1 antibody; Scn9a antibody; SCN9A_HUMAN antibody; Sodium channel protein type 9 subunit alpha antibody; Sodium channel protein type IX subunit alpha antibody; Sodium channel voltage gated type IX alpha antibody; Sodium channel voltage gated type IX alpha polypeptide antibody; Sodium channel voltage gated type IX alpha subunit antibody; Voltage gated sodium channel alpha subunit Nav1.7 antibody; Voltage gated sodium channel subunit alpha Nav1 antibody; Voltage-gated sodium channel subunit alpha Nav1.7 antibody
SEQUENCE SIMILARITIES
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily.
TISSUE SPECIFICITY
Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion.
POST-TRANSLATIONAL MODIFICATION
Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents.; Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.
SUBCELLULAR LOCATION
Cell membrane. Cell projection.
FUNCTION
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na+ channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.