Lane 1: SK-Br-3 cell lysate
Lane 2: 293 cell lysate
Mouse monoclonal primary
Myc-tag Monoclonal Antibody (EM1902-39)
Recombinant protein within human glutamine synthetase aa 190-373.
SK-Br-3 cell lysate, 293 cell lysate, human liver tissue, mouse liver tissue, THP-1.
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein G affinity purified.
Microsome, Cytosol, Mitochondrion, Cell membrane.
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants.