Lane 1: Hela
Lane 2: Mouse kidney tissue
Lane 3: K562
Mouse monoclonal primary
MTERFD1 Monoclonal Antibody (EM1701-29)
Hela, mouse kidney tissue lysate, K562, human liver tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
CGI 12 antibody; mitochondrial antibody; Mitochondrial transcription termination factor 3 antibody; MTER1_HUMAN antibody; MTERF domain containing 1 antibody; mTERF domain containing protein 1 mitochondrial antibody; mTERF domain-containing protein 1 antibody; mTERF3 antibody; Mterfd1 antibody; Transcription termination factor 3, mitochondrial antibody
Belongs to the mTERF family.
Highly expressed in heart, liver, kidney and testis. Detected at lower levels in brain, spleen and lung.
MTERFD1 belongs to the MTERF family which consists of four members including MTERF1, MTERF2, MTERF3 and MTERF4. Previous research showed that MTERFD1 is a mitochondrial protein that interacts with the mitochondrial DNA promoter region and decreases transcription initiation in mammalian mitochondria. This negative regulation is likely important for fine-tuning mitochondria transcription in response to physiological demands. Human mitochondrial transcription termination factor domain 1 (MTERFD1) was mutated in many types of cancer. In vivo and in vitro data indicated that MTERFD1 gene possesses oncogenic properties.