Lane 1: SKBR3
Lane 2: Raji
Lane 3: A431
Lane 4: A549
Rabbit polyclonal primary
MMP1 Antibody (ER31211)
A549, MCF-7, Raji, SKBR3, A431, human colon cancer tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified
Belongs to the peptidase M10A family.
Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.; Tyrosine phosphorylated in platelets by PKDCC/VLK.
Secreted, extracellular space, extracellular matrix.
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Wang, Ji et al.
Matrix metalloproteinase-1 expression in breast carcinoma: a marker for unfavorable prognosis. | Oncotarget