UNIPROT #

P03956

PROTEIN NAME

MMP1

SYNONYMS

27 kDa interstitial collagenase antibody; CLG antibody; CLGN antibody; collagenase, fibroblast antibody; collagenase, interstitial antibody; Fibroblast collagenase antibody; Interstitial collagenase antibody; Matrix metallopeptidase 1 (interstitial collagenase) antibody; Matrix metalloprotease 1 antibody; Matrix Metalloproteinase 1 antibody; Matrix metalloproteinase-1 antibody; MMP 1 antibody; MMP-1 antibody; MMP1 antibody; MMP1_HUMAN antibody; OTTHUMP00000045866 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M10A family.

POST-TRANSLATIONAL MODIFICATION

Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.; Tyrosine phosphorylated in platelets by PKDCC/VLK.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

MMP-1 has an archetypal structure consisting of a pre-domain, a pro-domain, a catalytic domain, a linker region and a hemopexin-like domain. Two main nomenclatures for the primary structure are currently in use, the original one from which the first amino-acid starts with the signalling peptide and a second one where the first amino-acid starts counting from the prodomain (proenzyme nomenclature). MMPs are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Specifically, MMP-1 breaks down the interstitial collagens, types I, II, and III. Mechanical force may increase the expression of MMP1 in human periodontal ligament cells.