Lane 1: HL-60 cell lysate
Lane 2: 293 cell lysate
Lane 3: PC-12 cell lysate
Lane 4: K562 cell lysate
Mouse monoclonal primary
MCM7 Monoclonal Antibody (EM1901-12)
Synthetic peptide within human aa 500-719.
HL-60 cell, 293 cell, PC-12 cell, K562 cell, human tonsil tissue, human esophagus tissue, SH-SY5Y cell.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
DNA replication licensing factor MCM7
Belongs to the MCM family.
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.