PRODUCT CODE: M1701-6

MAL Monoclonal Antibody (M1701-6)

Applications

  • WB

  • IHC-P

  • FC

REACTIVITY

  • Human

  • Mouse

  • Rat

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Western blot analysis of MAL on mouse kidney (1) and mouse lymphatic vessels (2) tissue lysate using anti-MAL antibody at 1/1,000 dilution.
  • Western blot analysis of MAL on mouse kidney (1) and mouse lymphatic vessels (2) tissue lysate using anti-MAL antibody at 1/1,000 dilution.
  • Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-MAL antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded rat kidney tissue using anti-MAL antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-MAL antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-MAL antibody. Counter stained with hematoxylin.
  • Flow cytometric analysis of Jurkat cells with MAL antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
Western blot analysis of MAL on mouse kidney (1) and mouse lymphatic vessels (2) tissue lysate using anti-MAL antibody at 1/1,000 dilution.

Applications

  • WB

  • IHC-P

  • FC

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Mouse monoclonal primary

Product Name

MAL Monoclonal Antibody (M1701-6)

Immunogen

Peptide

Host

Mouse

Positive Control

Mouse kidney tissue, mouse lymphatic vessels tissue lysate, rat brain tissue, rat kidney tissue, mouse brain tissue, Jurkat.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

B5-G3

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2 ug/ul

PURIFICATION

Peptide affinity purified

MOLECULAR WEIGHT

25 kDa

Isotype

IgG1

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:200

TARGET

UNIPROT #

PROTEIN NAME

MAL

SYNONYMS

mal antibody; MAL protein gene antibody; Mal T-cell differentiation protein antibody; MAL_HUMAN antibody; MALGENE antibody; MPV17 antibody; Myelin and lymphocyte protein antibody; T-cell differentiation protein MAL antibody; T-lymphocyte maturation-associated protein antibody; VIP17 antibody

SEQUENCE SIMILARITIES

Belongs to the MAL family.

DEVELOPMENTAL STAGE

Expressed in the intermediate and late stages of T-cell differentiation.

POST-TRANSLATIONAL MODIFICATION

Lipoprotein.

SUBCELLULAR LOCATION

Membrane. 

FUNCTION

MAL (myelin and lymphocyte protein), also known as T lymphocyte maturation-associated protein, is a nonglycosylated hydrophobic integral membrane protein belonging to the MAL family of proteolipids. MAL is highly enriched in nervous system myelin and in rafts and apical membranes of epithelial cells. It is involved in forming, stabilizing and maintaining glycosphingolipid-enriched membrane microdomains. MAL maintains the myelin sheath and, by controlling the sorting and trafficking of oligodendrocytes, it is involved in central nervous system paranode maintenance. MAL is a component of lipid rafts in myelinating cells. Association with glycosphingolipids may result in protein-lipid microdomain formation in myelin. MAL has been localized to the endoplasmic reticulum of T cells and in compact myelin of cells in the nervous system. MAL is primarily expressed by oligodendrocytes and Schwann cells in the intermediate and late stages of T cell differentiation.