UNIPROT #

P13473

PROTEIN NAME

LAMP2a

SYNONYMS

CD107 antigen-like family member B antibody; CD107b antibody; LAMP 2 antibody; Lamp 2a antibody; LAMP-2 antibody; LAMP2 antibody; LAMP2_HUMAN antibody; Lysosome-associated membrane glycoprotein 2 antibody; Lysosome-associated membrane protein 2 antibody

SEQUENCE SIMILARITIES

Belongs to the LAMP family.

TISSUE SPECIFICITY

Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver. Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta.

POST-TRANSLATIONAL MODIFICATION

O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.

SUBCELLULAR LOCATION

Plasma membrane. Endosome. Lysosome.

FUNCTION

Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107A) and LAMP-2 (also designated CD107B) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans Golgi network and are transported intracellularly via a pathway that is distinct from the clathrin-coated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.