KMT5A/SETD8/Pr-SET7 Recombinant Rabbit Monoclonal Antibody [JM73-43] (ET1705-59)

UNIPROT #

Q9NQR1

PROTEIN NAME

KMT5A/SETD8/Pr-SET7

SYNONYMS

H4 K20 HMTase antibody;H4 K20 specific histone methyltransferase antibody;H4-K20-HMTase SETD8 antibody;Histone H4 K20 methyltransferase antibody;Histone lysine N methyltransferase H4 lysine 20 specific antibody;Histone-lysine N-methyltransferase SETD8 antibody;Lysine N-methyltransferase 5A antibody;N-lysine methyltransferase SETD8 antibody;Pr SET 7 antibody;Pr SET7 antibody;PR-Set7 antibody;PR/SET domain containing protein 07 antibody;PR/SET domain containing protein 8 antibody;PR/SET domain-containing protein 07 antibody;PR/SET07 antibody;PrSET7 antibody;SET 07 antibody;SET 8 antibody;SET domain containing (lysine methyltransferase) 8 antibody;SET domain containing 8 antibody;SET domain containing lysine methyltransferase 8 antibody;SET domain containing protein 8 antibody;SET domain-containing protein 8 antibody;SET07 antibody;SET8 antibody;SETD 8 antibody;setd8 antibody;SETD8_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.

DEVELOPMENTAL STAGE

Not detected during G1 phase. First detected during S through G2 phases, and peaks during mitosis (at protein level).

POST-TRANSLATIONAL MODIFICATION

Acetylated at Lys-172; does not change methyltransferase activity. Deacetylated at Lys-172 by SIRT2; does not change methyltransferase activity.; Ubiquitinated and degraded by the DCX(DTL) complex.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. All monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions , benef playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contribute to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53 / TP53 at 'Lys-382', leading to repress p53 / TP53-target genes.