Applications
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Dot-blot
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ICC
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IHC-P
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FC
REACTIVITY
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Human
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Mouse
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Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
ITPR2 Antibody (ER1803-65)
Immunogen
Recombinant protein within human itpr2 aa 1100-1450.
Host
Rabbit
Positive Control
HepG2, HT-29, SiHa, rat kidney tissue, human colon tissue, human breast tissue, mouse liver tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein affinity purified.
MOLECULAR WEIGHT
308 kDa
Isotype
IgG
APPLICATION DILUTION
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Dot-blot
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1:2,000-1:5,000
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ICC
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1:50-1:100
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IHC-P
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1:50 -1:200
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FC
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1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
ITPR2
SYNONYMS
4 antibody; 5-trisphosphate receptor antibody; Inositol 1 4 5 trisphosphate receptor type 2 antibody; Inositol 1,4,5-trisphosphate receptor type 2 antibody; Inositol 145 trisphosphate receptor type 2 antibody; InsP3 R2 antibody; InsP3R2 antibody; IP3 R2 antibody; IP3 receptor antibody; IP3 receptor isoform 2 antibody; IP3R 2 antibody; IP3R2 antibody; ITPR 2 antibody; Itpr2 antibody; ITPR2_HUMAN antibody; Type 2 inositol 1 4 5 trisphosphate receptor antibody; Type 2 inositol 1 antibody; Type 2 inositol 145 trisphosphate receptor antibody; Type 2 InsP3 receptor antibody
SEQUENCE SIMILARITIES
Belongs to the InsP3 receptor family.
TISSUE SPECIFICITY
Isoform Short is found in skeletal muscle and heart.
POST-TRANSLATIONAL MODIFICATION
Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
SUBCELLULAR LOCATION
Endoplasmic reticulum membrane.
FUNCTION
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.