Rabbit polyclonal primary
iNOS Antibody (ER1706-89)
A549, LOVO, human tonsil tissue, human spleen tissue, mouse small intestine tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze/thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified
Nitric oxide synthase, inducible
HEP-NOS, Inducible NOS, iNOS, NOS2, NOS2A
Belongs to the NOS family.
Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.
Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation.
Cytoplasm, cytosol. Note=Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization.
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8.