Rabbit polyclonal primary
IL18 binding protein Antibody (ER1902-36)
Recombinant protein within n-terminal human il18 binding protein.
K562 cell lysates, LOVO, rat spleen tissue, human spleen tissue, mouse spleen tissue, A549.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
Predicted band size 21 kDa.
IL18 binding protein
I18BP_HUMAN antibody; IL-18BP antibody; IL18 binding protein antibody; IL18 BP antibody; IL18 BPa antibody; IL18BP antibody; IL18BPa antibody; Interleukin 18 binding protein antibody; Interleukin-18-binding protein antibody; MC51L 53L 54L homolog gene product antibody; Tadekinig alfa antibody; Tadekinig-alfa antibody
Strongly expressed in heart, lung, placenta and spleen.
N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4.
IL-18BP is a constitutively secreted protein, with an exceptionally high affinity for IL-18 (400 pM). Present in the serum of healthy humans at a 20-fold molar excess compared to IL-18, IL-18BP may contribute to a default mechanism by which a Th1 response to foreign organisms is blunted in order to reduce triggering an autoimmune responses to a routine infection. IL-18BP deviates from the classical definition of soluble receptors since it does not correspond to the extracellular ligand binding domain of the IL-18 receptor, but is rather encoded by a separate gene. Thus IL-18BP belongs to a separate family of secreted proteins.IL-18BP contains only one IgG domain whereas the Type II IL-1 receptor contains three domains. In this regard, the single IgG domain of IL-18BP is similar to SIGIRR, which also has a single IgG domain and also functions as a decoy receptor. The salient property of IL-18BP in immune responses is in down-regulating Th1 responses by binding to IL-18 and thus reducing the induction of IFNγ. Since IL-18 also affects Th2 responses, IL-18BP also has properties controlling a Th2 cytokine response.