Positive control:
Lane 1: Mouse liver tissue
Lane 2: Human kidney tissue
Lane 3: Rat kidney tissue
Lane 4: SiHa
Applications
-
WB
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
IL17RB Antibody (ER1706-26)
Immunogen
Recombinant protein
Host
Rabbit
Positive Control
Mouse liver tissue lysate, human kidney tissue lysate, rat kidney tissue lysate, SiHa.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein A purified.
MOLECULAR WEIGHT
56 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500-1:1,000
TARGET
UNIPROT #
PROTEIN NAME
IL17RB
SYNONYMS
CRL 4 antibody; CRL4 antibody; Cytokine receptor CRL4 antibody; EVI 27 antibody; EVI27 antibody; IL 17 receptor B antibody; IL 17 receptor homolog 1 antibody; IL 17B receptor antibody; IL 17RB antibody; IL 17Rh1 antibody; IL17BR antibody; IL17RB antibody; IL17RH1 antibody; Interleukin 17 receptor B antibody; Interleukin 17 receptor homolog 1 antibody; Interleukin 17 receptor homolog antibody; Interleukin 17B receptor antibody; MGC5245 antibody
TISSUE SPECIFICITY
Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.
SUBCELLULAR LOCATION
Single-pass type I membrane protein. Secreted.
FUNCTION
Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. IL-17RB is a member of the cytokine receptor family and acts as a receptor for the proinflammatory cytokines IL-17B and IL-17E. It may play a role in hematopoietic cell differentiation and growth. IL-17RB expression is high in liver, colon, brain, kidney and testis. IL-17RB is detected in fibroblast-like synoviocytes of rheumatoid arthritis patients.