hnRNP G-T Recombinant Rabbit Monoclonal Antibody [JE64-33] (HA721104)

UNIPROT #

O75526

PROTEIN NAME

hnRNP G-T

SYNONYMS

Heterogeneous nuclear ribonucleoprotein G T antibody;hnRNP G T antibody;hnRNP G-T antibody;HNRNPG T antibody;HNRNPGT antibody;HNRPGT antibody;RBMX L2 antibody;RBMXL 2 antibody;RBMXL2 antibody;RMXL2_HUMAN antibody;RNA binding motif protein X linked like 2 antibody;RNA-binding motif protein antibody;Testes specific heterogenous nuclear ribonucleoprotein G T antibody;Testis-specific heterogeneous nuclear ribonucleoprotein G-T antibody;X-linked-like-2 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility.