HLA DMB Recombinant Rabbit Monoclonal Antibody [JE58-74] (HA720038)

UNIPROT #

P28068

PROTEIN NAME

HLA DMB

SYNONYMS

class II antigen HLA-DM beta chain antibody;class II histocompatibility antigen antibody;Class II histocompatibility antigen M beta chain antibody;D6S221E antibody;DMB antibody;HLA class II histocompatibility antigen DM beta chain antibody;HLA-DM histocompatibility type, beta chain antibody;M beta chain antibody;Major histocompatibility complex class II DM beta antibody;MHC class II antigen DMB antibody;MHC class II antigen HLA DM beta chain antibody;MHC class II HLA DMB antibody;OTTHUMP00000029257 antibody;Really interesting new gene 7 protein antibody;RING 7 antibody;RING7 antibody

SUBCELLULAR LOCATION

Late endosome membrane, Lysosome membrane.

FUNCTION

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.