Lane 1: SH-SY5Y cell lysate
Lane 2: A549 cell lysate
Mouse monoclonal primary
Hip1 Monoclonal Antibody (EM1901-04)
Synthetic peptide within human hip1 aa 8-31.
SH-SY5Y, A549, rat brain tissue, human colon cancer tissue, human prostate cancer tissue, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Huntingtin-interacting protein 1
HIP-1, HIP-I, Hip1, Kiaa4113
Belongs to the SLA2 family.
Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.