Rabbit polyclonal primary
Heme Oxygenase 1 (HO-1) Antibody (ER1802-73)
Synthetic peptide of n-terminal human heme oxygenase 1 (ho-1).
Mouse spleen tissue lysate, 293T, HepG2, human spleen tissue, human placenta tissue, human small intestine tissue, mouse small intestine tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Heme oxygenase 1
HO-1, HMOX1, HO, HO1
Belongs to the heme oxygenase family.
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.