Applications
-
WB
-
IHC-P
-
FC
REACTIVITY
-
Human
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
GSDMC Antibody (ER1902-22)
Immunogen
Recombinant protein within human gsdmc aa 1-200.
Host
Rabbit
Positive Control
Human stomach tissue lysates, human lung tissue, human kidney tissue, A549.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein affinity purified.
MOLECULAR WEIGHT
Predicted band size 58 kDa.
Isotype
IgG
APPLICATION DILUTION
-
WB:1:1,000-1:2,000
-
IHC-P:1:50-1:200
-
FC:1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
GSDMC
SYNONYMS
Gasdermin C antibody; Gasdermin-C antibody; GSDMC antibody; GSDMC_HUMAN antibody; Melanoma derived leucine zipper, extra nuclear factor antibody; Melanoma-derived leucine zipper-containing extranuclear factor antibody; MLZE antibody
SEQUENCE SIMILARITIES
Belongs to the gasdermin family.
TISSUE SPECIFICITY
Expressed mainly in trachea and spleen. In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium.
SUBCELLULAR LOCATION
Cell membrane, cytosol.
FUNCTION
The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable).