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PRODUCT CODE: ER10708

GPR49/LGR5 alpha/beta Antibody (ER10708)

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

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Western blot analysis of LGR5 on different cell lysates using anti- VCP antibody at 1/1000 dilution.<br /> Positive control:<br /> Lane 1: F9<br /> Lane 2: Hela<br /> Lane 3: K562
  • Western blot analysis of LGR5 on different cell lysates using anti- VCP antibody at 1/1000 dilution.<br /> Positive control:<br /> Lane 1: F9<br /> Lane 2: Hela<br /> Lane 3: K562
  • Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-LGR5 antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-LGR5 antibody. Counter stained with hematoxylin.
Western blot analysis of LGR5 on different cell lysates using anti- VCP antibody at 1/1000 dilution.
Positive control:
Lane 1: F9
Lane 2: Hela
Lane 3: K562

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

GPR49/LGR5 alpha/beta Antibody (ER10708)

Immunogen

Peptide

Host

Rabbit

Positive Control

F9, Hela, K562, human liver tissue, human colon cancer tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Peptide affinity purified

MOLECULAR WEIGHT

95 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IHC-P

  • 1:200

TARGET

UNIPROT #

O75473

PROTEIN NAME

GPR49/LGR5 alpha/beta

SYNONYMS

FEX antibody; G protein coupled receptor 49 antibody; G protein coupled receptor 67 antibody; g protein-coupled receptor fex antibody; G-protein coupled receptor 49 antibody; G-protein coupled receptor 67 antibody; G-protein coupled receptor HG38 antibody; GPR 49 antibody; GPR 67 antibody; GPR49 antibody; GPR67 antibody; GRP 49 antibody; GRP49 antibody; HG 38 antibody; HG38 antibody; Leucine rich repeat containing G protein coupled receptor 5 antibody; Leucine-rich repeat-containing G-protein coupled receptor 5 antibody; LGR 5 antibody; LGR5 antibody; LGR5_HUMAN antibody; MGC117008 antibody; Orphan G protein coupled receptor HG38 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.

SUBCELLULAR LOCATION

Cytoplasm, cell membrane.

FUNCTION

G-protein coupled receptor GPR49 (also known as Leucine-rich repeat-containing G-protein coupled receptor 5, Lgr5) is a stem cell marker of the intestinal epithelium and the hair follicule. It is expressed in the gonads, the adrenal gland, and in the brain, overexpressed in cancers of the ovary, colon and liver.