UNIPROT #

Q9H2U9

PROTEIN NAME

Gp83

TISSUE SPECIFICITY

Not detected in healthy melanocytes. Expressed in melanoma cells.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein.